2023年 第45卷 总目次

2023年 第45卷 总目次

第1期

编委推荐................(1)

热点追踪

两个拮抗的bHLH转录因子对水稻种子休眠的调控.......................... 金晶，储成才(3)

特邀综述

遗传修饰猪模型在生物医学及农业领域研究进展及应用...................................... 高菲，王煜，杜嘉祥，杜旭光，赵建国，潘登科，吴森，赵要风(6)

综 述

遗传性耳聋分子诊断及梯级检测策略应用............... 曾焙枰，许红恩，毛璐，汤文学(29)

诱导多能干细胞在儿童疾病的应用研究进展.................................... 田智琛，尹晓娟(42)

研究报告

转录组分析在血液样本时间和供体特征刻画中的应用研究............................ 张瑾，刘开会，张颖，郝金萍，张广峰，徐小玉，畅晶晶，刘兴朋，杨雪莹，叶健(52)

过表达组蛋白H3K9me3去甲基化酶对猪克隆胚胎发育的影响............................ 李亚楠，张贤君，张宁，梁雅琳，张宇星，招华兴，李紫聪，黄思秀(67)

实验操作指南

利用CRISPR/Cas9技术构建基因编辑大鼠模型......................... 刘梅珍，王立人，李咏梅，马雪云，韩红辉，李大力(78)

遗传资源

一例X染色体结构重排导致DMD疾病....................胡浩，杨晓文，程德华，李秀蓉，何文斌，胡晓，高伯笛，赵晓蒙，张前军，杜娟，刘激扬，卢光琇，林戈，李汶(88)

撤稿声明

撤稿：诱导多能干细胞技术及其在疾病研究中的应用[遗传,2020,42(11):1042–1061]...................(95)

综合信息

致谢2022年度审稿编委和审稿专家...................(96)

第2期

编委推荐...................(97)

综 述

核受体REV-ERBα整合生物钟与能量代谢......................... 冒姝羽，赵昌睿，刘畅(99)

FSCN1在乳腺癌发生发展中的作用及其调控机制....................................... 常栋，刘享享，刘睿，孙建伟(115)

基因渗入的检测和表征方法........................... 刘泽璇，赵毅强(128)

研究报告

脂肪细胞促进高脂饮食诱导肥胖.......................... 王澜，曾帆，黄荣凤，林树，张志辉，李旻典(144)

甘蓝DELLA基因家族鉴定及其mRNA在嫁接体中的运输分析.................................. 李必元，赵彦婷，岳智臣，雷娟利，胡齐赞，陶鹏(156)

实验操作指南

CRISPR-Cas9基因编辑技术对细胞内源蛋白进行荧光标记的实验操作..................................... 吴仲胜，高誉，杜勇涛，党颂，何康敏(165)

遗传学教学

以A2型短指(趾)症为案例的医学遗传学PBL教学设计............. 马捷，黄露杰，张巧霞，朱艳，钱露(176)

第3期

编委推荐................(185)

优博专栏

跨组织线粒体应激信号交流调控机体衰老研究进展................... 张茜，王子豪，田烨(187)

综 述

单细胞转录组测序在少突胶质谱系细胞异质性与神经系统疾病中的应用.............................. 韩熙，罗富成(198)

组织蛋白酶B参与脑衰老及阿尔兹海默症发生发展研究进展......................... 商晓康，张思萌，倪军军(212)

果蝇限制端粒转座子的分子机制............................. 王承贤，容益康，崔敏(221)

JAK/STAT信号通路及其对昆虫免疫的调控......................... 韦湘怡，胡冬春，高祖鹏，冯从经(229)

研究报告

基于WGCNA发掘缺磷、红光和黄光处理下三角褐指藻岩藻黄素合成关键基因.......................... 吕娇，龚一富，章丽，胡媛，王何瑜(237)

技术与方法

用于循环肿瘤细胞定量分析的数字PCR检测方法的建立及性能验证.................................... 马春辉，胡海旭，张丽娟，刘毅，刘天懿(250)

遗传资源

一例以多发性骨破坏为显著特征的老年戈谢病的诊疗和基因检测分析......................... 秦姝超，尹华，王蓉，朱飞鹏，李建勇，卢瑞南(261)

第4期

编委推荐....................(271)

前沿聚焦

哺乳动物卵子与早期胚胎中全转录组poly(A)尾研究进展................. 王文龙，张春霞(273)

综 述

Hi-C 技术在三维基因组学和疾病致病机理研究中的应用.......... 王舜泽，江丰，朱东丽，杨铁林，郭燕(279)

绵羊突变对BMPR1B活性及BMP/SMAD通路的影响研究进展...................................... 龚一鸣，王翔宇，贺小云，刘玉芳，余平，储明星，狄冉(295)

可视化分析在病原体核酸现场快速检测中的研究进展........................... 刘丹妮，武海萍，周国华(306)

研究报告

利用人类全基因组亚硫酸氢盐测序数据检测CNVs的研究............................ 徐丹同，王祎菲，蔡佳丽，龚文滔，潘向春，田雨晗，沈箐鹏，李加琪，袁晓龙(324)

尿囊素促进破骨细胞缺陷斑马鱼骨折修复.............................. 李凯伦，卢荆奥，陈小辉，张文清，刘伟(341)

遗传学教学

现代计算机技术在遗传学实验教学中的应用——移动端轻量级高精度果蝇遗传性状批量识别系统的开发 .......................安钧浩，赵雪莹，乔守怡，卢大儒，皮妍(354)

第5期

编委推荐....................(365)

优博专栏

水稻分蘖氮响应调控机理研究进展................. 刘永强，李威威，刘昕禹，储成才(367)

综 述

哺乳动物卵母细胞的DNA损伤与修复研究进展....................... 张楠，张珏，林戈(379)

STIM1在肿瘤发生及转移中的研究进展........... 严程浩，白韦钰，张智猛，沈俊岭，王友军，孙建伟(395)

生物钟作用机制及其对动物年节律产生的影响................. 杨阳，储明星，刘秋月(409)

研究报告

生酮饮食激活脂肪酸氧化促进ME区的少突胶质细胞前体细胞增殖.......................... 王奔，李斯，吴青峰，穆文辉(425)

miR-196b-5p促进成肌细胞增殖分化....................... 吴玲玲，张小玉，李晓，靳建军，杨公社，史新娥(435)

鸡基因组及转录本结构分析................................. 高智慧，黄佳新，罗昊玉，徐海冬，娄明，宁博林，邢晓旭，牟芳，李辉，王宁(447)

勘 误

勘误：CRISPR/Cas9系统在林木基因编辑中的应用.............................. 陈赢男，陆静(446)

第6期

编委推荐....................(459)

热点追踪

杂交物种形成促进哺乳动物多样性演化—以金丝猴属()为例.......... 章誉兴，吴宏，于黎(461)

前沿聚焦

外显子拼接复合体塑造m6A表观转录组的形成............... 宋鹏辉，马丽娟，严冬(464)

综 述

6-甲基腺苷修饰对女性生殖系统功能的影响......................... 何山，赵健，宋晓峰(472)

两侧对称动物左右不对称发生机制研究进展............... 邢超凡，王闽涛，王磊，申欣(488)

植物质体基因工程调控元件研究进展....................................... 于一凡，欧阳臻，郭娟，赵瑜君，黄璐琦(501)

研究报告

基因新突变导致卵母细胞成熟阻滞为特征的女性不孕................................. 吕香江，郭静，林戈(514)

金鱼草基因克隆与功能研究................................. 李菲菲，郝燕敏，崔敏龙，朴春兰(526)

遗传资源

一例基因复合杂合变异所致的肢带型肌营养不良症2U型的诊断和基因检测分析............................ 黄娟，缪文华，郭晓峰，吉炜(536)

第7期

编委推荐....................(543)

领域动态

国外畜禽遗传资源保护及对我国的启示................................... 陈晓，陆健，于福清(545)

综 述

发育性和癫痫性脑病遗传学病因及诊疗的研究进展............... 金良，陈语婕，陈勇军(553)

伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病的发病机制及治疗研究进展.............................. 张翌，吴志英(568)

研究报告

E2F家族转录因子在肿瘤发生中的作用................. 李飞飞，王韵，顾冀海，张玉明，柳峰松，倪志华(580)

利用单转录本表达Cas9和sgRNA条件性编辑果蝇基因组..................... 王秉政，张超，张佳丽，孙锦(593)

全基因组重测序解析秦川牛保种群遗传多样性和遗传结构........................................ 马钧，樊安平，王武生，张金川，江晓军，马瑞军，贾社强，刘飞，雷初朝，黄永震(602)

遗传资源

一例婴儿神经轴索营养不良的诊疗与基因检测分析..................... 宫为大，陶钢，赵甜甜，杨悦，纪红(617)

会议简讯

第一届全国遗传领域标准化论坛暨中国遗传学会标准化技术委员会成立大会在上海成功召开............ 郭云峰，许俊(624)

第8期

编委推荐....................(627)

热点追踪

菌源同工酶分析揭示菌源DPP4同工酶是潜在的抗2型糖尿病靶点................. 张志威，汪锴，姜长涛(629)

综 述

线粒体DNA碱基编辑技术研究进展....................... 宋睿嘉，韩露，孙海峰，沈彬(632)

痛风的多组学研究进展................. 时文睿，渠鸿竹，方向东(643)

研究报告

AFF4在人类HEL细胞中广泛地影响RNA聚合酶II的停滞释放............................... 杨子玫，张格，魏刚，经莉莉，于明(658)

数据驱动的人体正常和癌症组织中糖基磷脂酰肌醇锚定蛋白(GPI-AP)相关基因表达谱的综合分析........................... 孔维泽，柳艺石，高晓冬，藤田盛久(669)

巨噬细胞相关基因与非小细胞肺癌预后和肿瘤微环境的分析....................................... 孙清玙，周阳，杜丽娟，张梦珂，王家乐，任媛媛，刘芳(684)

铁皮石斛WOX家族基因在生长发育中的功能分析......................... 陈凯，王灏，陈燚婷，符可，韩之刚，李聪，斯金平，陈东红(700)

第9期

前 言

作物分子设计育种与从头驯化...................... 谭禄宾，孙传清(715)

综 述

水稻分子设计育种启示：传统与现代相结合............ 卞中，曹东平，庄文姝，张舒玮，刘巧泉，张林(718)

从头驯化：作物品种设计与培育的新方向..................... 简六梅，肖英杰，严建兵(741)

植物开花调控中蛋白质相分离机制在从头驯化中的应用价值............................ 田璐妍，黄小珍(754)

长雄野生稻有利基因的发掘与利用.......................... 廉小平，黄光福，张玉娇，张静，胡凤益，张石来(765)

同源四倍体水稻：低育性机理、改良与育种展望...................................... 刘向东，吴锦文，陆紫君，Muhammad Qasim Shahid(781)

大豆光周期适应性研究进展.................... 赖笔威，陈磊，芦思佳(793)

氮素调控花生共生结瘤的机制研究进展...... 曾瑞儿，耿庆辉，高恒宽，潘晴晴，陈婷婷，陈勇，张雷(801)

植物小肽信号生物学功能及其在作物改良中研究进展..................... 吕倩雯，杨永芳(813)

遗传资源

中科发早粳1号分子设计育种................... 陈明江，刘贵富，肖叶青，余泓，李家洋(829)

研究报告

水稻调控籽粒大小与株型.................................... 郑镇武，赵宏源，梁晓娅，王一珺，王驰航，巩高洋，黄金燕，张桂权，王少奎，刘祖培(835)

通过合成不同活性GA调控水稻育性及株高....................................... 郝小花，胡爽，赵丹，田连福，谢子靖，吴莎，胡文俐，雷晗，李东屏(845)

第10期

编委推荐....................(857)

综 述

大规模平行报告基因测定：一种分析基因表达调控的新技术................................... 袁萌，李辉，王守志(859)

溶酶体酶PPT1介导的细胞稳态调控及疾病发生的研究进展......................... 周欣怡，常栋，徐黄莹，关瑞琪，严程浩，尹秋媛，孙建伟(874)

噬菌体Z基因组生物合成通路的研究进展........................................ 陈荟玉，赵素文(887)

研究报告

基于比较基因组学的解脂亚罗酵母CA20高产赤藓糖醇机理及进化分析........................................ 夏凯，刘芳美，陈雨晴，陈珊珊，黄春莹，赵学群，沙如意，黄俊(904)

基于机器学习的猪生长性状基因组预测............................ 陈栋，王书杰，赵真坚，姬祥，申琦，余杨，崔晟頔，王俊戈，陈子旸，王金勇，郭宗义，吴平先，唐国庆(922)

技术与方法

基于全局最小残差法快速分析混合STR图谱............................. 李鑫，范虹，赵兴春，范晓诺，姚若侠(933)

第11期

前 言

解析病原体与宿主相互作用机制 应对全球新发突发传染病挑战................ 谢建平，肖永红，周钢桥(945)

综 述

CRISPR基因组编辑技术在传染病致病机理研究和防诊治中的应用................................ 杨臻嵘，周钢桥(950)

新冠肺炎遗传易感基因的研究进展...................... 李元丰，吴天准，陈顺琦，王玉婷，曾涛，李若凡，周钢桥(963)

甲型流感病毒宿主适应的分子基础及其相关宿主因子的研究进展.......................... 孙婷婷，岑山，王静(976)

病原体逃逸宿主固有免疫的新策略：抑制细胞焦亡........................................ 杨茂艺，崔潇月，郑诗棋，马诗瑶，郑增长，邓万燕(986)

USP18介导的蛋白质去ISG化及其在结核病等传染病中的作用.................................. 张其奥，王子路，李佩波，谢建平(998)

鸟苷酸结合蛋白家族在感染性疾病中调控炎症小体活化的研究进展.................. 全舒婷，焦伟伟，徐放，孙琳，綦辉，申阿东(1007)

分枝杆菌非典型错配修复及其在抗生素耐药中的研究进展............... 向莎莎，谢建平(1018)

艰难梭菌抗菌药物耐药机制研究进展.................... 胥腾，黄海辉(1028)

研究报告

hsa_circ_0007460通过调节巨噬细胞的自噬和凋亡影响细胞内结核分枝杆菌的存活.................................... 章金怡，何禹墨，周晶雨，翁术锋，马慧霞，林太玥，徐颖(1039)

糖尿病与非糖尿病患者社区获得性高毒肺炎克雷伯菌肝脓肿临床及病原学特征比较.................................. 叶静，王媛，熊璐颖，肖永红(1052)

两起发热伴血小板减少综合征聚集性疫情流行病学及病原学分析.............................. 杨鑫，武永祥，冷昱，李佳宸，王超杰，袁义美，王震，张兰，黎浩，刘玮(1062)

杭州地区2012～2018年耐甲氧西林金黄色葡萄球菌的分子流行病学特征及其变化趋势............................. 朱云颖，王媛，肖婷婷，嵇金如，沈萍，肖永红(1074)

第12期

编委推荐....................(1085)

特邀综述

人类卵母细胞减数分裂的生理和病理机制................................... 周舟，桑庆，王磊(1087)

综 述

分枝杆菌T7SS(ESX)分泌系统功能研究进展................................... 蒋智勇，谢建平(1100)

基因芯片在畜禽遗传育种中的应用及展望.............. 汪佳豪，赵卿尧，周月玲，史良玉，王楚端，俞英(1114)

研究报告

丝状真菌AA11家族裂解多糖单加氧酶基因的鉴定和功能研究..................................... 杜文珍，李元敬，吴佳玲，陈思羽，姜亮，刘刚，谢宁(1128)

宁乡猪皮下脂肪与肌内脂肪组织转录组差异分析........................... 王芳，张跃博，蒋谦，印遇龙，谭碧娥，陈家顺(1147)

遗传学教学

基于科教融合培养大学生拔尖创新能力的表观遗传学综合实验课程.......................... 欧秀芳，吴莹，李宁，姜丽丽，刘宝，宫磊(1158)

No. 1

Invited Review

Advances and applications of genetically modified pig models in biomedical and agricultural field.......................... Fei Gao,Yu Wang,Jiaxiang Du,Xuguang Du,Jianguo Zhao,Dengke Pan,Sen Wu,Yaofeng Zhao(6)

Review

Molecular diagnosis of hereditary deafness and application of stepwise testing strategy.............................. Beiping Zeng,Hongen Xu,Lu Mao,Wenxue Tang(29)

Advances in the application of induced pluripotent stem cells in pediatric diseases....................... Zhichen Tian,Xiaojuan Yin(42)

Research Article

Application of transcriptome in time analysis and donor characterization in blood samples........................................ Jin Zhang,Kaihui Liu,Ying Zhang,Jinping Hao,Guangfeng Zhang,Xiaoyu Xu,Jingjing Chang,Xingpeng Liu,Xueying Yang,Jian Ye(52)

Effects of overexpression of histone H3K9me3 demethylase on development of porcine cloned embryos................................ Yanan Li,Xianjun Zhang,Ning Zhang,Yalin Liang,Yuxing Zhang, Huaxing Zhao,Zicong Li,Sixiu Huang(67)

Protocol

Generation of genetically modified rat models via the CRISPR/Cas9 technology........................................ Meizhen Liu,Liren Wang,Yongmei Li,Xueyun Ma,Honghui Han,Dali Li(78)

Genetic Resource

A DMD case caused by X chromosome rearrangement ................................. Hao Hu,Xiaowen Yang,Dehua Cheng,Xiurong Li,Wenbin He,Xiao Hu,Bodi Gao, Xiaomeng Zhao,Qianjun Zhang,Juan Du,Jiyang Liu,Guangxiu Lu,Lin Ge,Wen Li(88)

No. 2

Review

The nuclear receptor REV-ERBα integrates circadian clock and energy metabolism..................................................... Shuyu Mao,Changrui Zhao,Chang Liu(99)

The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression............................................................... Dong Chang,Xiangxiang Liu,Rui Liu,Jianwei Sun(115)

Methods to detect and characterize introgression................... Zexuan Liu,Yiqiang Zhao(128)

Research Article

Adipocyte reconstitution ofgene insilenced mice promotes diet-induced obesity..................................................... Lan Wang,Fan Zeng,Rongfeng Huang,Shu Lin,Zhihui Zhang,Min-Dian Li(144)

Identification of DELLA gene family in head cabbage and analysis of mRNA transport in the heterograft.............................. Biyuan Li,Yanting Zhao,Zhichen Yue,Juanli Lei,Qizan Hu,Peng Tao(156)

Protocol

The protocol of tagging endogenous proteins with fluorescent tags using CRISPR-Cas9 genome editing.................................... Zhongsheng Wu,Yu Gao,Yongtao Du,Song Dang,Kangmin He(165)

Genetics Teaching

PBL teaching design of medical genetics with the case of brachydactyly type A2............................................ Jie Ma,Lujie Huang,Qiaoxia Zhang,Yan Zhu,Lu Qian(176)

No. 3

Special Section: Excellent Doctoral Thesis

Inter-tissue communication of mitochondrial stress in aging......................... Qian Zhang,Zihao Wang,Ye Tian(187)

Review

Application of single-cell RNA sequencing in probing oligodendroglia heterogeneity and neurological disorders............................. Xi Han,Fucheng Luo(198)

Research progress of cathepsin B in brain aging and Alzheimer’s diseases............................................. Xiaokang Shang,Simeng Zhang,Junjun Ni(212)

The molecular mechanism ofrestricting telomeric transposons............................................ Chengxian Wang,Yikang S. Rong,Min Cui(221)

JAK/STAT signaling pathway and its regulation on insect immunity........................................................ Xiangyi Wei,Dongchun Hu,Zupeng Gao,Congjing Feng(229)

Research Article

Exploring the key genes of fucoxanthin biosynthesis inunder phosphorus deficiency, red light and yellow light using WGCNA..........................................Jiao Lv,Yifu Gong,Li Zhang,Yuan Hu,Heyu Wang(237)

Technique and Method

Establishment and verification of a digital PCR assay for the detection ofexpression in quantitative analysis of circulating tumor cell.......................... Chunhui Ma,Haixu Hu,Lijuan Zhang,Yi Liu,Tianyi Liu(250)

Genetic Resource

Diagnosis,treatment and genetic analysis of an elderly patient with Gaucher’s disease characterized by marked multiple bone destruction.................... Shuchao Qin,Hua Yin,Rong Wang,Feipeng Zhu,Jianyong Li,Ruinan Lu(261)

No. 4

Frontier Focus

Research progress on the study of transcriptome-wide poly(A) tails in mammalian oocytes and early embryos....................... Wenlong Wang,Chunxia Zhang(273)

Review

Application of Hi-C technology in three-dimensional genomics research and disease pathogenesis analysis............................... Shunze Wang,Feng Jiang,Dongli Zhu,Tie-Lin Yang,Yan Guo(279)

Progress on the effect ofmutation on BMPR1B activity and BMP/SMAD pathway in sheep........................................... Yiming Gong,Xiangyu Wang,Xiaoyun He,Yufang Liu,Ping Yu,Mingxing Chu,Ran Di(295)

Research progress of visual detection in rapid on-site detection of pathogen nucleic acid............................................................ Danni Liu,Haiping Wu,Guohua Zhou(306)

Research Article

Study on detection of CNVs using human whole genome bisulfite sequencing data...................................................... Dantong Xu,Yifei Wang,Jiali Cai,Wentao Gong,Xiangchun Pan,Yuhan Tian,Qingpeng Shen,Jiaqi Li,Xiaolong Yuan(324)

The role of the allantoin in promoting fracture healing in osteoclast-deficient zebrafish.............................................................. Kailun Li,Jingao Lu,Xiaohui Chen,Wenqing Zhang,Wei Liu(341)

Genetics Teaching

Application of modern computer technology in classical genetics lab course——Development of a mobile, lightweight and high-precision batch identification system for genetic traits of........................................ Junhao An,Xueying Zhao,Shouyi Qiao,Daru Lu,Yan Pi(354)

No. 5

Special Section: Excellent Doctoral Thesis

Molecular mechanism of tillering response to nitrogen in rice........................................................ Yongqiang Liu,Weiwei Li,Xinyu Liu,Chengcai Chu(367)

Review

Advances in the study of DNA damage and repair in mammalian oocytes................................................... Nan Zhang,Jue Zhang,Ge Lin(379)

The roles and mechanism of STIM1 in tumorigenesis and metastasis........................................................... Chenghao Yan,Weiyu Bai,Zhimeng Zhang,Junling Shen,Youjun Wang,Jianwei Sun(395)

The mechanism of circadian clock and its influence on animal circannual rhythm........................................... Yang Yang,Mingxing Chu,Qiuyue Liu(409)

Research Article

Ketogenic diet promotes the proliferation of oligodendrocyte precursor cells in ME region by activating fatty acid oxidation.......................... Ben Wang,Si Li,Qing-Feng Wu,Wenhui Mu(425)

miR-196b-5p promotes myoblast proliferation and differentiation............................................................ Lingling Wu,Xiaoyu Zhang,Xiao Li,Jianjun Jin,Gongshe Yang,Xin’e Shi(435)

Characterization of the genomic and transcriptional structure of chickengene ..................................Zhihui Gao,Jiaxin Huang,Haoyu Luo,Haidong Xu,Ming Lou, Bolin Ning,Xiaoxu Xing,Fang Mu,Hui Li,Ning Wang(447)

No. 6

Frontier Focus

Exon junction complex modulates the formation of the m6A epitranscriptome........................................... Penghui Song,Lijuan Ma,Dong Yan (464)

Review

Effects of6-methyladenosine modification on the function of the female reproductive system.................................................... Shan He,Jian Zhao,Xiaofeng Song (472)

Progress on the mechanism of left-right asymmetrical patterning in bilaterians................................................ Chaofan Xing,Mintao Wang,Lei Wang,Xin Shen(488)

Progress on regulatory elements of plant plastid genetic engineering........................................................... Yifan Yu,Zhen OuYang,Juan Guo,Yujun Zhao,Luqi Huang(501)

Research Article

Novel mutations inlead to female infertility with oocyte maturation arrest.......................................................... Xiangjiang Lv,Jing Guo,Ge Lin(514)

Cloning and functional analysis ofgene from...................................................... Feifei Li,Yanmin Hao,Minlong Cui,Chunlan Piao(526)

Genetic Resource

Diagnosis and genetic testing analysis of limb-girdle muscular dystrophy type 2U caused by a compound heterozygous mutation in thegene........................... Juan Huang,Wenhua Miao,Xiaofeng Guo,Wei Ji(536)

No. 7

Research Trends

Conservation of animal genetic resources in the world and its enlightenment to China..................................................... Xiao Chen,Jian Lu,Fuqing Yu(545)

Review

Advances in genetic etiology,diagnosis and treatment of developmental and epileptic encephalopathy....................................... Liang Jin,Yujie Chen,Yongjun Chen(553)

Pathogenesis and therapeutic advances of cerebral autosomal- dominant arteriopathy with subcortical infarcts and leukoencephalopathy.................... Yi Zhang,Zhi-Ying Wu(568)

Research Article

E2F family play important roles in tumorigenesis.................................................... Feifei Li,Yun Wang,Jihai Gu,Yuming Zhang,Fengsong Liu,Zhihua Ni(580)

Conditional editing of thegenome using single transcripts expressing Cas9 and sgRNA................... Bingzheng Wang,Chao Zhang,Jiali Zhang,Jin Sun(593)

Analysis of genetic diversity and genetic structure of Qinchuan cattle conservation population using whole-genome resequencing ..................................... Jun Ma,Anping Fan,Wusheng Wang,Jinchuan Zhang, Xiaojun Jiang,Ruijun Ma,Sheqiang Jia,Fei Liu,Chuchao Lei,Yongzhen Huang(602)

Genetic Resource

Diagnosis,treatment and genetic analysis of a child with infantile neuroaxonal dystrophy.............................................................. Weida Gong,Gang Tao,Tiantian Zhao,Yue Yang,Hong Ji (617)

No. 8

Review

Advances in mitochondrial DNA base editing technology.......... Ruijia Song,Lu Han,Haifeng Sun,Bin Shen(632)

Overview of multi-omics research in gout.......................... Wenrui Shi,Hongzhu Qu,Xiangdong Fang(643)

Research Article

AFF4 globally affects the release of paused RNA polymerase II in HEL cells............................................ Zimei Yang,Ge Zhang,Gang Wei,Lili Jing,Ming Yu(658)

Comprehensive in silico analysis of glycosylphosphatidylinositol- anchored protein(GPI-AP) related genes expression profiles in human normal and cancer tissues Weize Kong,Yishi Liu,Xiaodong Gao,Morihisa Fujita...............................(669)

Analysis between macrophage-related genes with prognosis and tumor microenvironment in non-small cell lung cancer............... Qingyu Sun,Yang Zhou,Lijuan Du,Mengke Zhang,Jiale Wang,Yuanyuan Ren,Fang Liu(684)

Functional analysis of WOX family genes induring growth and development........................................ Kai Chen,Hao Wang,Yiting Chen,Ke Fu,Zhigang Han,Cong Li,Jinping Si,Donghong Chen(700)

No. 9

Review

Revelation of rice molecular design breeding: the blend of tradition and modernity.......................................................... Zhong Bian,Dongping Cao,Wenshu Zhuang,Shuwei Zhang,Qiaoquan Liu,Lin Zhang(718)

domestication: a new way for crop design and breeding.......................... Liumei Jian,Yingjie Xiao,Jianbing Yan(741)

Application value of protein phase separation mechanism of flowering regulation indomestication.............................. Luyan Tian,Xiaozhen Huang(754)

The discovery and utilization of favorable genes in.................................................. Xiaoping Lian,Guangfu Huang,Yujiao Zhang,Jing Zhang,Fengyi Hu,Shilai Zhang(765)

Autotetraploid rice: challenges and opportunities..................................................... Xiangdong Liu,Jinwen Wu,Zijun Lu,Muhammad Qasim Shahid(781)

The current status of photoperiod adaptability in soybean...................................... Biwei Lai,Lei Chen,Sijia Lu(793)

Mechanism of symbiotic nodulation between nitrogen and peanut................................................................ Ruier Zeng,Qinghui Geng,Hengkuan Gao,Qingqing Pan,Tingting Chen,Yong Chen,Lei Zhang(801)

The biological functions of peptide signaling in plant and the advances on its utilization for crop improvement............................ Qianwen Lv,Yongfang Yang(813)

Genetic Resource

Breeding of ZhongKeFaZaoGeng1 by molecular design................................................ Mingjiang Chen,Guifu Liu,Yeqing Xiao,Hong Yu,Jiayang Li(829)

Research Article

controls kernel size and plant architecture in rice.......................................... Zhenwu Zheng,Hongyuan Zhao,Xiaoya Liang,Yijun Wang,Chihang Wang,Gaoyan Gong,Jinyan Huang,Guiquan Zhang,Shaokui Wang,Zupei Liu(835)

genes regulate rice fertility and plant height by synthesizing diverse active GA.............................................................. Xiaohua Hao,Shuang Hu,Dan Zhao,Lianfu Tian,Zijing Xie,Sha Wu,Wenli Hu,Han Lei,Dongping Li(845)

No. 10

Review

Massively parallel reporter assay: a novel technique for analyzing the regulation of gene expression........................................... Meng Yuan,Hui Li,Shouzhi Wang(859)

Progress on lysosomal PPT1-mediated regulation of cellular homeostasis and pathogenesis........................................................... Xinyi Zhou,Dong Chang,Huangying Xu,Ruiqi Guan,Chenghao Yan,Qiuyuan Yin,Jianwei Sun(874)

Progress on Z genome biosynthetic pathway of bacteriophage..................................... Huiyu Chen,Suwen Zhao(887)

Research Article

Mechanism and evolutionary analysis ofCA20 capable of producing erythritol with a high yield based on comparative genomics........................... Kai Xia,Fangmei Liu,Yuqing Chen, Shanshan Chen,Chunying Huang,Xuequn Zhao,Ruyi Sha,Jun Huang(904)

Genomic prediction of pig growth traits based on machine learning............................................................. Dong Chen,Shujie Wang,Zhenjian Zhao,Xiang Ji,Qi Shen,Yang Yu,Shengdi Cui,Junge Wang,Ziyang Chen,Jinyong Wang,Zongyi Guo,Pingxian Wu,Guoqing Tang(922)

Technique and Method

Rapid analyzing mixed STR profiles based on the global minimum residual method........................................................ Xin Li,Hong Fan,Xingchun Zhao,Xiaonuo Fan,Ruoxia Yao(933)

No. 11

Review

The application of CRISPR genome editing technologies in the pathogenesis studies,diagnosis,prevention and treatment of infectious diseases................................... Zhenrong Yang,Gangqiao Zhou(950)

Progresses on genetic susceptibility of COVID-19............................................... Yuanfeng Li,Tianzhun Wu,Shunqi Chen,Yuting Wang,Tao Zeng,Ruofan Li,Gangqiao Zhou(963)

Progress on viral and host determinants of influenza A virus species specificity........................................... Tingting Sun,Shan Cen,Jing Wang(976)

Inhibiting pyroptosis: novel immune evasion strategies for pathogens..................................................... Maoyi Yang,Xiaoyue Cui,Shiqi Zheng,Shiyao Ma,Zengzhang Zheng,Wanyan Deng(986)

USP18-mediated protein deISGylation and its role in tuberculosis and other infectious diseases............................................... Qi’ao Zhang,Zilu Wang,Peibo Li,Jianping Xie(998)

Advances in the regulation of inflammasome activation by GBP family in infectious diseases Shuting Quan,Weiwei Jiao,Fang Xu,Lin Sun,Hui Qi,Adong Shen..............................(1007)

Progress on the non-canonical mismatch repair inand its role in antibiotic resistance..................................... Shasha Xiang,Jianping Xie (1018)

Progress on mechanisms of antibiotic resistance in.................. Teng Xu,Haihui Huang(1028)

Research Article

Hsa_circ_0007460 affects the survival of intracellularby regulating autophagy and apoptosis of macrophages......................................... Jinyi Zhang,Yumo He,Jingyu Zhou,Shufeng Weng,Huixia Ma,Taiyue Lin,Ying Xu(1039)

Comparison of clinical and microbiological characteristics of community-acquired hypervirulentliver abscess in diabetic and non-diabetic patients......................................................... Jing Ye,Yuan Wang,Luying Xiong,Yonghong Xiao(1052)

Epidemiololgical and etiological analysis of two clusters of severe fever with thrombocytopenia syndrome.......................... Xin Yang,Yongxiang Wu,Yu Leng,Jiachen Li,Chaojie Wang,Yimei Yuan,Zhen Wang,Lan Zhang,Hao Li,Wei Liu(1062)

Molecular epidemiology and change trend of methicillin-resistantfrom invasive infections of a hospital in Hangzhou from 2012 to 2018..................................... Yunying Zhu,Yuan Wang,Tingting Xiao,Jinru Ji,Ping Shen,Yonghong Xiao(1074)

No. 12

Invited Review

Physiological and pathological mechanisms of oocyte meiosis...................... Zhou Zhou,Qing Sang,Lei Wang(1087)

Review

Progress on the function ofT7SS(ESX) secretion system........... Zhiyong Jiang,Jianping Xie(1100)

Application and prospect of gene chip in genetic breeding of livestock and poultry...................................................... Jiahao Wang,Qingyao Zhao,Yueling Zhou,Liangyu Shi,Chuduan Wang,Ying Yu(1114)

Research Article

Identification and functional study of AA11 family polysaccharide monooxygenase genes in filamentous fungus............................... Wenzhen Du,Yuanjing Li,Jialing Wu,Siyu Chen,Liang Jiang,Gang Liu,Ning Xie(1128)

Analysis of transcriptome differences between subcutaneous and intramuscular adipose tissue of Ningxiang pigs .................................... Fang Wang,Yuebo Zhang,Qian Jiang,Yulong Yin,Bi’e Tan,Jiashun Chen (1147)

Genetics Teaching

Epigenetics comprehensive experimental course based on the integration of science and education to cultivate students' ability of cutting-edge innovation....................................................... Xiufang Ou,Ying Wu,Ning Li,Lili Jiang,Bao Liu,Lei Gong(1158)

（卷终）